Large Chromatin Domains Drive Pancreatic Cancer’s Sugar RushFebruary 14, 2017A sugar rush can fuel many things. It can power the late-night experiments demanded by reviewer number 3 or it can drive tumor evolution. Fueled by both these factors, new insight into the linked metabolic-epigenetic mechanisms of metastasis comes at you from a collaborative effort led by the lab of Andrew Feinberg in the Center […]
Histone Modification Imaging Pr-EDICTS Stem Cell FateJanuary 27, 2017Will it rain? Will my team win? Will I get that grant? There are instances where a glance into a fortune-teller’s crystal ball could definitely give you the upper hand. Although the crystal ball is a myth, researchers from the lab of Prabhas V. Moghe (Rutgers University, New Jersey, USA) have recently developed a means […]
Mapping mRNA Methylation in the Mouse: From ESCs to the BrainJanuary 23, 2017As Ptolemy and other noteworthy cartographers will tell you, a detailed and up-to-date map is always useful. This navigational tool has guided many intrepid explorers from familiar regions towards the unknown with the promise of discovery and adventure! In the linear world of ribonucleic acid (RNA), intrepid researchers have mapped the locations of the N6-methyladenosine […]
RICC-seq Uses Gamma Rays to Smash out Nucleosome-Nucleosome InteractionsJanuary 17, 2017Gamma rays can give super powers to scientific insight, whether it be PET scans, the Epigenetic Hulk, or nucleosome-nucleosome interactions. While we’ve seen a lot about the primary structure of single nucleosomes and the tertiary structure of large chromatin loops, it seems that the 1–3 nucleosome (50–500 bp) architecture known as secondary structure has been […]
Anti-CRISPRs Provide A Kill Switch For Cas9January 6, 2017The post-holiday party period is always an excellent time to reflect that there can always be too much of a good thing. Whether it’s cookies, champagne, or Bing Crosby, sometimes you just need an off-switch. The same can be true of Cas9 – leaving it turned on after your gene editing is done, or leaky […]