Not Just Monkey Business: circRNAs are Dynamic in the Aging Non-Human Primate BrainSeptember 28, 2018While we tend to grow out of monkey business and running in circles as we grow older, exciting new profiles of brain circular RNA (circRNA) dynamics during normal aging have emerged thanks to these two youthful tactics. This insightful research into non-human primates comes from the groups of Jiali Li (University of the Chinese Academy […]
Egg-ceptional Role of Retrotransposon Transcription in Depositing DNA MethylationSeptember 25, 2018What do the mammalian genome and an old storage unit have in common? They’re both full of so-called junk. But unlike your aunt’s box of glass figurines, the junk in the human genome has turned out to have a lot of value. Most the “junk” in the human genome arose from retrotransposons. Long terminal repeat […]
Recycling: Keeping the Planet Green and the Histone Modification Landscape Pristine!September 22, 2018Recycling represents one of the most important strategies to keep the planet clean and green for generations to come. Used paper, metal, and plastic and other assorted detritus generally encounter a second use, but can we recycle the histone proteins that help to package our DNA and maintain cell-type-specific transcriptional programs? A lean, clean, and […]
Forget a Moment on the Lips, DNA Methylation Disruptions from a Night Without Sleep Could Mean ‘Forever’ on the HipsSeptember 20, 2018While staring at the alarm clock isn’ta great way to catch a healthy night’s sleep, the lull of our circadian rhythm most certainly is. The circadian clock keeps our cells and their epigenomes in shape by maintaining synchrony with the day, and now new findings from the lab of Christian Benedict at Uppsala University (Sweden) […]
Chromatin Domain Boundary Issues Turn Short Tandem Repeats PathogenicSeptember 11, 2018Boundary issues between countries can start wars, while boundary issues between people cause personal space problems; but can boundary issues between repetitive loci lead to the development of human disorders? The pathogenesis of the disorders in question, which include fragile X syndrome (FXS), Huntington’s disease, amyotrophic lateral sclerosis, and Friedreich’s ataxia, involves the unstable expansion […]
