Common DNA Methylation Aging Profiles Convert Dog to Human Years Better Than EverJuly 20, 2020They say you can’t teach an old dog new tricks, but it turns out you can use new epigenomic tricks to tell you how old a dog is. The heuristic that to get a dogs age in human years, you multiply by seven is a little simplistic, and due for an update using epigenomic insights. […]
rChIP-Seq Ratifies RNA as a Requirement for PRC2 to Rock and RollJuly 20, 2020Once in a while, an epigenetic technique comes along to rock your world more than your favorite Led Zeppelin or Foo Fighters album! Now, a band of researchers fronted by the dynamic duo of John L. Rinn and Thomas R. Cech (University of Colorado, Boulder, CO, USA) has just released a chart-topping masterpiece with their […]
H4K16ac Marks an Intergenerational To-Do List for Developing Fly EmbryosJuly 7, 2020Do the laundry? Check. Buy fabric softener? Got it. Write that next manuscript? Working on it… We’ve all got a lot on our to-do lists these days, but it’s nothing compared to the checklist that developing drosophila embryos have to contend with. On top of coordinating histone methylation marks, they’ve got to prepare for a […]
Filling in the Blanks: DNA Methylation-Dependent Glycosylation of Chromatin Modifiers Represses TranscriptionJuly 7, 2020You might think our portrait of the marks that make up the epigenetic landscape is nearing completion, but a new feature is now filling in some of the blank space behind a key regulatory mechanism. It has been long known that DNA methylation represses transcription via the recruitment of methylation-dependent repressive factors. The components of […]
Early-Life BPA Exposure Accelerates Epigenetic Aging and Creates a Ticking Timebomb for Metabolic Disease that a Western Diet IgnitesJuly 3, 2020While we hope that any silly errors and childish pranks of our formative years don´t follow us into adulthood, it now seems that certain experiences during early development are indeed carried into adulthood without our knowledge, where an activating trigger can lead to trouble and strife! Specifically, exposure to any number of environmental stressors during […]
