Distant Genomic Regions Meet at DNA Methylation Grand CanyonsJune 9, 2020CpG islands have been the best-known tourist destination in the epigenome for a long time, but if you’re looking for a change there’s a destination that all the rage: DNA methylation grand canyons. It is well known that DNA methylation at CpG islands is associated with transcriptional repression. However, the precise molecular mechanism linking DNA […]
Transgenerational Epigenetic Inheritance in Worms is A “Tail” of Two NucleotidesJune 2, 2020While the sprawls of London and Paris take center stage in the novel “A Tale of Two Cities,” we now seek to narrate an alternative epigenetic “tail” that tells all about two nucleotides! In this hefty tome, uridine and guanosine play the starring roles in a story passed down through generations and generations of worms; […]
A Rewired Metabolism Links the Aging Epigenome to Vision LossMay 16, 2020They say hindsight is 20/20, but for those of us looking over at a lifetime of memories, things might seem a little blurrier through our aging eyes. That’s because, unlike the fine wines, delectable whiskies, and smelly cheeses that we love to catabolize, the human epigenome tends not to age very well and a wide […]
Preprint Alert: Single-nucleus Mouse Brain Atlases of DNA Methylation and Chromatin AccessibilityMay 15, 2020When exploring the epigenetic landscape, it’s easy to get lost in the jungle of cell types. Thankfully, some exciting new preprints now bring forth much needed single-nucleus atlases to guide your voyage of the mouse brain. We’re no strangers to cunning cartography that has emerged from the lab of Joe Ecker (Salk Institute, California). They’ve […]
Cannabis and Tobacco Produce a Double Hit on the EpigenomeMay 12, 2020While the epigenetic impacts of cannabis have been seen in sperm and adolescents, the effects on adults have not been well studied in large-scale studies. It’s commonly believed that smoking cannabis is less damaging than smoking tobacco; however, this is not backed by an abundance of actual data. Smoking tobacco is associated with numerous DNA […]
