TET2 Overtrims the Methylation Hedges at Enhancers in Parkinson’s Disease NeuronsAugust 25, 2020It takes real restraint to prevent a routine hedge trim from turning into a horticultural horror show; and like an overzealous landscaper, new research shows that TET2 may be mowing down the methylome in Parkinson’s Disease (PD) neurons. The cognitive and motor symptoms of PD are caused by the degeneration of dopamine-producing neurons in the […]
Epitranscriptomic tRNA Study Finally Reveals the “Y” of Aggressive Colon TumorsAugust 25, 2020Away with you Holmes, begone Poirot, and bye-bye Nancy Drew, because a terrific team of epigenetic detectives has solved an epitranscriptomic cold case to reveal the “Y” of aggressive colon tumors by linking CpG island promoter DNA hypermethylation of a key epitranscriptomic modifier and a transfer RNA (tRNA) modification to tumorigenesis. Epitranscriptomics includes the modification […]
Exosomal microRNA Roots for Regrowth by Raising Hairs in Retired FolliclesAugust 15, 2020Move over, Rogaine; the pharmacies of the future will carry hair regrowth treatments that contain microRNAs from hair follicle exosomes! There are creams, supplements, lasers and even surgery, but people struggling with hair loss still don’t have a convenient and effective treatment to help them restore their luscious locks. New treatments could involve injecting dermal […]
Cell free DNA MeDIP-seq is a Molecular Methylation Magnet for Machine Learning Cancer DetectionAugust 7, 2020Finding the cell free DNA (cfDNA) that most cell-types release into blood plasma is always a challenging task, but certain cancers release so little that it takes looking for a needle in a haystack to the next level. Methods for sorting the “hay” have often come up short, but two new studies successfully developed a […]
Cutting Through the Smog of Mitochondrial DNA Methylation after Prenatal Pollution ExposureAugust 7, 2020While everyone loves hearing about a scientific controversy, clearing the air can also provide a sense of satisfaction. So, sit back and take a breath of the fresh air that an environmentally conscious team brings to the controversy surrounding mitochondrial (mt)DNA methylation through their examination of prenatal exposure to environmental stressors such as air pollution […]
