Special Multiomics Feature: Combinatorial DNA Methylation and Chromatin Assays Serve Up New InsightNovember 9, 2020Combinations of old favorites can be even tastier than the sum of their parts. Who doesn’t leave peanut butter and jam, chips and dip, and DNA methylation and chromatin assays? While they sound appetizing, those last two aren’t quite as easy to get together. Many assays have been developed in the past to combine ChIP […]
Long-Sperm Effects: THC and Nicotine Have A Lasting Impact on Bivalent Chromatin and Autism GenesNovember 4, 2020While some fathers planning a family may be left in a bivalent state when deciding about smoking cannabis or nicotine, new research has cleared the air. THC and nicotine both prime an autism spectrum disorder profile in sperm through altering DNA methylation within bivalent chromatin states. In their seminal paper, researchers from the lab of […]
Low-Pass WGBS of Newborn Dried Blood Spots: A Methylome-Wide Role for the RUNX1 Super-Enhancer in Down SyndromeOctober 23, 2020While collecting blood spots may seem like a hobby best left for a TV serial killer like Dexter Morgan, a novel low-pass whole-genome bisulfite sequencing (WGBS) approach has shown that newborn dried blood spots are more than just a trophy. Their entire methylome can be assayed to answer enticing epigenomic enigmas. DNA methylation array studies have […]
X Marks the Spot for Neurodevelopment in the Autism Spectrum Disorder Cord Blood MethylomeOctober 19, 2020Every good pirate knows that X marks the spot on their treasure map, but what’s one to do when it’s surrounded by the dangers of uncharted territory? Thankfully, when it comes to the unexplored regions of the Autism Spectrum Disorder (ASD) DNA methylome, whole genome bisulfite sequencing (WGBS) has illuminated the way to the X chromosome […]
Multi-omic Analyses Highlight an Epigenetic Treatment Strategy for Early-stage Alzheimer’sOctober 19, 2020Given the unfortunate failure of many treatment strategies for late-stage Alzheimer’s disease, researchers recently sought to gain some fresh new perspective from multiple angles by mounting a three-pronged transcriptomic, proteomic, and epigenomic attack to decipher the mechanisms controlling disease progression. Excitingly, the team behind this study now highlight the possibility of an early-stage epigenetic therapy […]
