reChIP Doubles Down on Low-input Profiling of Bivalent ChromatinMarch 5, 2024Sometimes, when you’re dealt the right hand, doubling down is a sound strategy. Although it can be a risky move in blackjack, a new ChIP-seq method makes it a sure thing when you’re dealing with bivalent chromatin. The strategy, which includes important preparation steps and two rounds of chromatin immunoprecipitation (ChIP), provides sensitive genome-wide profiles […]
Updated cfDNA Nucleosomics Technology Upgrades our Epigenetic ClocksMarch 4, 2024A new style, novel functionalities, and a better overall product; we always want our smartwatches to employ the latest technology, and why not?! Now, a well-timed update involving cell-free DNA (cfDNA) nucleosomics-based technology provides for a significantly upgraded epigenetic clock, which may boost aging-based research. A punctual team led by Vladimir B. Teif (University of […]
FORGEdb Deciphers Genetic Variants and Disease Mechanisms to Tell Whether Your Gene Regulation Mechanism is a Touchdown or a Field Goal!February 26, 2024Performing experiments to understand gene regulation and do not want to miss any extra points? Well, FORGEdb may be the method for you! Building on previous research, this new method can help scientists unravel the mysteries behind complex diseases by identifying candidate functional variants and uncovering target genes and mechanisms. Developed by a team led […]
SIMPLE-seq Collaborates Chemistries to Report Single-Cell 5mC and 5hmCFebruary 20, 2024Collaborations work best when team members’ abilities complement each other. That’s what makes SIMPLE-seq work so well—it’s a simple, easy combination of two methods that complement each other to provide both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) datasets in one experiment in single cells and molecules. Continuing on the recent theme of methods that report both 5mC […]
Relax and Let NanoSPA Analyze m6A and Ψ RNA Mods for YouFebruary 20, 2024We could all use a spa day once in a while, so light some lavender-scented candles, take a deep breath, and let NanoSPA analyze the RNA modifications in your samples. This new nanopore sequencing analysis pipeline provides data on both N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications at the same time, reducing stress and saving time. Instead […]
