Dynamic Pseudouridylation of ncRNA and mRNADecember 15, 2014Pseudouridine (Ψ) is not only the most abundant post-translational modification (PTM) of RNA in all organisms, but it is also amongst the first discovered, way back in the futuristic 50’s, where it was deemed the 5th nucleotide of RNA. Ψ doesn’t discriminate against cellular functions or evolutionary distinct species. And while studied intently in rRNA […]
Epigenetic Exploitation of Host Cells by VirusesDecember 14, 2014Exploitation is a common theme in all fields of biology and viruses are no exception. But now it seems that viruses are up to some creative tricks when it comes to keeping a low profile in preparation for their full attack and sneaking out a few infections, a process known as viral latency. While DNA methylation may function as […]
Epigenetics Mediates Immortality of Adult Stem CellsDecember 13, 2014What would you do to ensure your immortality? Drink a potion? Cast a spell? Or even set out on an expedition to find the fountain of youth? Researchers from the Adult Stem Cell Technology Centre in Boston, USA have discovered that adult stem cells in the mouse have another more intricate strategy towards living forever […]
Newly Evolved Ribozyme Is Proof-of-principle for the Origin of LifeDecember 13, 2014Life is complicated. While that does apply to ordering your daily caffeine fix at Starbucks, what we’re talking about here is darwinian, entropy-defying, self-replicating life. Just to store, read, and apply genetic information requires 3 different types of molecules: DNA, RNA, and proteins. That makes it tough to imagine how life could ooze into being in […]
Reprogramming to Pluripotency: Lessons from the EggDecember 8, 2014Have you ever wish you could just clone yourself? How much more work you’d be able to get done in a day! While creating an exact copy of yourself that knows everything you do is still very much in the realms of science fiction, cloning human cells is a reality. The first big leap came […]