Chromatin Modifications in EnhancersMarch 20, 2013Enhancers serve as distal regulators of gene expression, but insights into the precise mechanisms of enhancer chromatin modifications are still lacking. In this recent review, Calo and Wysocka summarized various enhancer-associated modifications and propose how these modifications regulate enhancer activity during development. Here are some of the key topics discussed: The Enhancer Chromatin Landscape Enhancers […]
The 3D Genome: A Review into Genomic Organization and its Key PlayersMarch 20, 2013Our genome is not linear. Nope, it’s a three-dimensional labyrinth of regulatory nooks and crannies . Gibcus and Dekker recently published this free review that looks at the spatial hierarchy of genomic organization and how it modulates gene expression. This is a great resource for those of you looking to beef up your understanding of […]
Engineering (Epi)Genomes with CRISPR-CasMarch 14, 2013To really figure out what genes really do, you gotta get in there and get your hands dirty. That usually means deleting or modifying genes, or other regulatory regions. In a recent “Research Highlight” article, researchers at Johns Hopkins reviewed the three main ways to do this, including the increasingly popular CRISPR/Cas system. To engineer […]
DNA Methylation in Cancer Goes the Distance via EnhancersMarch 14, 2013We like having all the important things close by—a stash of chocolate, a latte, and the remote control. But sometimes important things are far away. Take enhancers, for example. Enhancers are often pretty far from the genes whose transcription they are “enhancing.” And now, it turns out that DNA methylation at these enhancers can affect […]
New Epigenetic Modifications Poster from AbcamMarch 13, 2013Abcam’s updated their epigenetics modifications map just in time for your lab spring cleaning, so why not spruce up your space with this beauty? Free Abcam Epigenetic Modifications Poster Download Here >>> Put an end to lame conversations about the weather. Hang this beauty above […]
