Hacking the Microbiome: Bacteria Advance Therapeutics and DiagnosticsAugust 5, 2015Commensal bacteria have long had branding issues. First there was an awareness problem – “Wait, these things are inside us?” Then there was an image problem – “Germs! Bad! Kill!” They even had a Pluto moment, when it turned out a whole bunch of them weren’t even bacteria at all. Despite these difficulties, the word […]
Lights Out! Sleep Loss Affects DNA Methylation of Circadian GenesAugust 4, 2015 ‘La nuit blanche’. No, it is not a delicious pastry. It’s the French expression for staying up all night and not going to bed until the next evening, which in most cases will leave you pretty irritable. But losing one night’s sleep may affect more than just your mood; a new study by Swedish […]
Wanted: Serially-Offending Epigenetic Enzymes Implicated In CancerAugust 4, 2015Epigenetic enzymes are among the prime suspects in the identity parade of genes responsible for the deregulation of the genome in cancer. But are the same epigenetic enzymes always found at the scene of the crime? A new analysis from a team of international researchers led by Andrew Teschendorff identifies three epigenetic enzymes that can […]
DNA Methylation Helps T Cells with their Career PathAugust 3, 2015In one of the lower valleys of Waddington’s epigenetic landscape, T cells are confronted with a fatal decision: Become a CD4+ helper T cell and assist your brethren in fighting evil invaders or turn into a CD8+ cytotoxic T cell and do the dirty work. But as in all good fantasy novels, our heroes first […]
Webinar: Multiplex Profiling of Epigenetic Modifications – Measuring Assay Specific & Off-target Effects in the Same SampleJuly 29, 2015Abstract: A variety of epigenetic modifications including post-translational modifications (PTMs) on histone tails regulate gene expression and have profound effects on cell signaling and human disease. N-terminal histone tails can have a variety of modifications, such as phosphorylation, methylation and acetylation at specific amino acid residues which are conserved throughout eukaryotes and function by altering chromatin […]
