A Super-specific Epigenetic Editing Strategy Silences Disease-associated Dominant MutationsNovember 22, 2023Is it a bird? Is it a plane? No, it’s a “super” new study that combines the strength, ability, and ingenuity of epigenetic editing to shut down our nemesis – the disease-associated dominant mutation – while leaving the innocent bystander allele unharmed! Epigenetic superheroes led by Albert Jeltsch (University of Stuttgart) aimed to battle their […]
The Brain Cell Census: A Deeper Epigenomic Understanding of the Mammalian MainframeNovember 13, 2023If you have epigenetics on the brain like us, concentrate your mammalian mainframe on the recently published marvels on the brain’s epigenome from the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative – Cell Census Network (BICCN). Recent work brought together under the guise of the Brain Cell Census now reports on the examination […]
Differential Methylation Data Are Quick, Easy, and Inexpensive with FML-seqNovember 7, 2023Sometimes you just want to get straight to the point. Along those lines, FML-seq (fragmentation at methylated loci and sequencing) cuts to the chase by providing a quick look at differential methylation data without the labor and expense of other approaches. Granted, some methods like whole-genome bisulfite sequencing (WGBS) tell you where every methylation event is, […]
5hmC Stands Apart from 5mC Through Single-Cell Multi-omic MethodsOctober 23, 2023Sometimes, you really want to stand out from the crowd. For years, 5-hydroxymethylcytosine (5hmC) has lurked in the shadows, often lumped together with 5-methylcytosine (5mC). However, these modifications have different effects—5mC generally turns down expression and 5hmC ramps it up. Sure, several methods can tease apart 5mC and 5hmC, but they require a lot of sample […]
Kacme: A New Histone Modification Couples Methylation and Acetylation to Mark Active TranscriptionOctober 23, 2023Some couples seem unlikely, yet somehow, they work (a recent pop star-football player pair comes to mind). Now, an even more surprising couple—a methyl group and an acetyl group—hanging out together on the very same lysine residues on histone H4s has just been spotted across species and appears to be involved in active transcription. Mind. […]
