GAM SLICEs Through Enhancer ThreesomesMarch 24, 2017While chromosome conformation capture (3C) methods like single-cell Hi-C focus on coupled pairs of chromosome contacts, and even their promiscuous regions, candid snapshots of chromosomal threesomes have remained an intimate secret … until now. The genomic architects in the labs of Ana Pombo and Mario Nicodemi developed a new method and accompanying statistical model to […]
CAGE Releases an Accurate Atlas of lncRNA Origin and FunctionMarch 21, 2017Don’t you just hate when you’re trying to get from A to B and google maps can’t even figure out where you’re starting from? Well, just like your last trip to that hot new sushi place, the precise location of lncRNA origins has only been plotted with blurry lines. Thankfully, to aid the start of […]
Gene Body DNA Methylation Keeps Cells Fit and HealthyMarch 9, 2017Boots, check! Helmet, check! DNA Methylation, check? Any active individual will tell you that protecting your body is an integral part of keeping fit and healthy while enjoying your sport of choice. In the über-competitive world of DNA, a study from the teams of Francesco Neri and Salvatore Oliviero has proposed that DNA methylation on […]
Single and Ready to Mingle: Single-Cell Bisulfite Sequencing Gives Up Its Intimate SecretsMarch 9, 2017Ever fancy a go with a new technique only to find that the methods section of the paper is holding out on the most intimate details? While single-cell bisulfite sequencing (scBs-seq) has been lusted after by many a researcher, mingling with those single cells has proved a bit more challenging. But fear not, the labs […]
Engineered Cells Treat Diabetic MiceFebruary 23, 2017Mmm… post-lunch blood glucose spike! Sitting down at my quiet computer, I can nearly hear my pancreatic islet cells working away, pumping out insulin to keep my blood glucose levels in check. Unfortunately, millions of people are not so well-protected from the glycemic havoc so mercilessly wreaked by chocolate cake. For people with type 1 […]