EpiGenie Book Reviews: EpigeneticsMarch 11, 2013If you’ve spent any time browsing the EpiGenie site, then you already know that we find epigenetics pretty interesting. So, of course any book with the title of Epigenetics is going to grab our attention. Epigenetics edited by Jörg Tost, gathers information from several top scientists working in various facets of epigenetics to assemble a […]
Epigenetics OnDemand: Free Presentations for DownloadMarch 11, 2013Our friends over at Hanson Wade have clued us in to some great free resources that are so nice, we’re officially referring to them as Handsome Wade now. Check out this greatest hits compilation of talks and presentations from industry and academic epigenetic gurus. Each of these can be downloaded, free of charge using the links below. […]
lncRNA Regulates Tumor Suppressor Two WaysMarch 4, 2013A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated. PTENpg1, a PTEN pseudogene, regulates PTEN via both sense […]
Correcting Brain Tissue Heterogeneity with DNA MethylationFebruary 28, 2013A few weeks ago, we highlighted some great work that has been very useful in helping correct for heterogeneous cell populations in blood. Now, we’ve just got wind of a clever new bioinformatics tool to correct for heterogeneity in the brain. Researchers have studied DNA methylation in brain tissue to see if there’s an association between that modification and […]
Guide: Peak Calling for ChIP-SeqFebruary 27, 2013Chromatin-immunoprecipitation sequencing (ChIP-seq) is the most widely used technique for analyzing Protein:DNA interactions. Very briefly, cells are cross-linked, fragmented and immunoprecipitated with an antibody specific to the target protein; the resulting ChIP DNA fragments are used as the template in a next-generation sequencing library preparation and many millions of short sequence reads are generated for […]
