CUT&Tag Launches to the Final Frontier: Spatial Epigenomic Profiling of Histone ModificationsMarch 14, 2022Space: the final frontier – CUT&Tag has just voyaged where no next-generation sequencing method has gone before to bring forth spatially-resolved histone modification profiles of intact mouse tissues! An expeditionary force led by Rong Fan (Yale University) combined in situ cleavage under targets and tagmentation (CUT&Tag) chemistry, microfluidic deterministic barcoding, and next-generation sequencing to develop […]
Webinar: Chromatin Immunoprecipitation (ChIP) Workshop – Dr. Toryn PoolmanFebruary 28, 2022If you’re new to chromatin immunoprecipitation (ChIP), or you’re thinking about giving it a try, you will want to take the time to watch this webinar first! Our friends at Proteintech put together an excellent workshop led by Dr. Toryn Poolman at University College London that covers a ton of tips and tricks that will […]
“Is this the real-life? Is this just fantasy?” – CultureAGE Shows How In Vitro Studies Reflect In Vivo Epigenetic AgingFebruary 21, 2022Profiling epigenetic aging with in vitro cell models may allow for a deeper understanding of the difficult-to-decipher in vivo process, but only if one truly reflects the other; this leaves us wondering: “Is this the real-life? Is this just fantasy?” In their epigenetic rock opera, bohemians from the lab of Morgan Levine (Yale School of […]
Can Disrupting Chromatin Interactions Stop SARS-CoV-2 in its Tracks?February 21, 2022Viral infections can appear like a runaway train, careering through the human body without a brake in sight; however, the meandering journey taken for the development of antivirals has now discovered a new way to stop runaway SARS-CoV-2 infections in their tracks thanks to CRISPR technology and a trip through the chromatin landscape of infected […]
Epigenetic “Baby-steps” Repress Germline Genome-defense During DevelopmentFebruary 4, 2022Much like a set of helping hands can guide, support, and protect a toddler taking their first steps, the guiding force of epigenetics during embryonic development ensures genome stability and supports healthy development by regulating the expression of key genes. Such genes include DNA methylation-sensitive “germline genome-defense” genes, which undergo DNA demethylation and become expressed […]
