SiTomics Captures Site-Specific Dynamic Histone Modifications, Proteome and Genome Changes In the WildMarch 22, 2023Don’t you wish you could just look into the nucleus of a cell and watch what’s happening? With SiTomics, Peng Chen’s lab (Peking University) gets close—they can see what modifications are being placed on a particular histone, what proteins bind to it, and where that histone is on the DNA, all in living cells. To do […]
Going Green! – How Histone Recycling Promotes the Preservation of Pristine Epigenetic LandscapesMarch 6, 2023The climate crisis and our need to produce less waste have made recycling an everyday concept; however, whether histone proteins “go green” during DNA replication has remained somewhat in doubt. The epigenetic environment becomes disrupted during DNA replication and must be restored to maintain genome regulation and cell identity; now, two high-efficiency epigenetic studies provide […]
One-Stop Sequencing: Simultaneous Genetic and Epigenetic InformationMarch 2, 2023Some shoppers like to browse several stores, whereas others follow the Amazon approach and want to just visit one place to buy everything on their list. The lab of Shankar Balasubramanian’s (University of Cambridge) must be in that second group because they developed a sequencing method that is a true one-stop extravaganza. It rings up […]
DNA Methylation Editing Provides Evidence for Transgenerational Epigenetic Inheritance in MammalsFebruary 26, 2023While we have become familiar with the link between DNA methylation and disease, an exciting epigenetic editing study now reports how DNA methylation contributes to transgenerational epigenetic inheritance in mammals and influences disease-associated traits across generations! In their previous study, a talented team led by Juan Carlos Izpisua Belmonte at the Salk Institute for Biological […]
Multiplexed Epigenome Editing Rouses a “Sleeping Dog” to Treat a Neurodevelopmental DisorderFebruary 20, 2023“Let sleeping dogs lie” is sound advice for those who want to stay out of trouble! However, an eye-opening epigenome editing study now suggests that rousing the “sleeping” methyl CpG-binding protein 2 (MECP2) gene from the inactive X chromosome may represent a therapeutic opportunity for girls with Rett Syndrome – an X-linked neurodevelopmental disorder that […]
