ChIP-String Ties Down Chromatin Regulator AnalysisMarch 22, 2012There are hundreds of chromatin regulators (CRs) out there, and yet we know so little about them other than that they control chromatin structure and function through interactions with histone mods. To help tie down the CR rules of engagement, some handy scientists developed the ChIP-string assay to provide a snapshot of several CRs in […]
Influenza Dodges Antiviral Response with Histone DisguiseMarch 22, 2012Imitation is the sincerest form of flattery, they say. But instead of flattery, the influenza virus (and maybe many other viruses) imitates histones to make people sick. That kind of flattery we could do without. Researchers in NY and the U.K. discovered that influenza A (H3N2)—one of the strains that cause seasonal flu outbreaks—hijacks the […]
ChIP and Discs: Porvair’s Chromatrap® ChIP Kits Break through the NoiseMarch 22, 2012Over the last decade, the ChIP process has seen more enhancements than the Orange County Housewives. Improved antibodies, beads, and fine-tuned buffers—they’ve all ChIP’d in to take this useful method primetime in labs all over the globe. But there’s always room for improvement. Turning Up the Pull Down for Small Sample ChIP Some of the […]
Bivalent PREs Protected by Perfect TimingMarch 21, 2012There’s no substitute for good timing. It’s a trait that can keep you out of a dangerous situation, or make you look good on the dance floor. But for cells it’s also critical for maintaining epigenetic states during replication. Italian researchers at the IRCCS Santa Lucia Foundation recently identified a critical time window right before […]
Webinar: Global and Locus-Specific 5-hmC DetectionMarch 21, 2012New England Biolabs is hosting a free webinar titled: Global and locus specific 5-hydroxymethylcytosine detection and quantification Tues. March, 27th 2012 at 9am PDT It will discuss simple and quick enzymatic methods for global, as well as sequence-specific, determination of both DNA modifications throughout various genomes. T4 phage B-glucosyltransferase has emerged as the enzyme of […]
