GEMS Makes the m6A RNA Modification Shine in Living CellsFebruary 5, 2024Unlike DNA or histone methylation, knowledge about N6-methyladenosine (m6A) modification of RNA is a little cloudy. It’s involved in some cancers and other diseases, but we don’t know as much about its expression in living cells. Now, a new method called GEMS makes m6A shine bright like a diamond for drug discovery and delivery of […]
Bilingual Proteins Establish and Maintain Heritable Silent Chromatin DomainsFebruary 5, 2024Whether you learn through hitting the books or traveling the globe – speaking two languages has many advantages. Now, a study into the basis of gene expression regulation reports how bilingual “read-write” proteins that “speak” two epigenetic languages can help us to learn about the complex mechanisms controlling sequence-independent heritable gene silencing. The dynamic duo […]
XIST’s X-istential Crisis: A New Role in Autosomal Gene RegulationJanuary 22, 2024The long non-coding RNA (lncRNA) XIST functions as an epigenetic silencer tightly linked to the X chromosome to balance gene expression between the sexes; however, this lncRNA now has a cause for concern as an autosomal gene regulatory function just pushed XIST into a full-blown “X-istential” crisis! Reports have described a dispersed XIST configuration in […]
uCoTarget Is a Single-Cell Multiomics Method for Multiple Histone ModificationsJanuary 17, 2024Everyone loves a bargain, and a new method called CoTarget really delivers. It’s a method that delivers single-cell multiomics data on multiple histone modifications and transcription factors, as well as the transcriptome. It can easily scale up to analyze a million single cells, and unlike similar methods, it doesn’t require microfluidic devices or special transposon […]
SSSavi: Savvy Epigenome Editing with Diverse, Orderly TeamsDecember 12, 2023Bringing in the right combination of people with different perspectives and abilities can take a team to new heights. And just like that savvy diverse team, a new epigenome editing tool called the Spy-Snoop-Sun-Avi (SSSavi) system recruits diverse effector molecules in an interchangeable and orderly way to understand how combinations of DNA and histone modifications […]
