Building Layers of Epigenome and Transcriptome Spatial Information in Single CellsMarch 27, 2023Layers make things a lot more interesting—a cake with chocolate, vanilla and strawberry layers is much more decadent than a single-tier vanilla one. And now the labs of Rong Fan (Yale University), Gonçalo Castelo-Branco (Karolinska Institute), and Yanxlang Deng (now at University of Pennsylvania) have put the icing on the cake with a new paper […]
H3K4 Methylation Loss Makes RNAPII Pause for ThoughtMarch 27, 2023With mice with two dads, crystal clear images of dying stars, and the rise of ChatGPT being daily news items, does anything make you “pause for thought” these days? A stunning study from reflective researchers just might! They provide insight into an epigenetic enigma surrounding the transcriptional role of a histone modification by reporting how […]
SiTomics Captures Site-Specific Dynamic Histone Modifications, Proteome and Genome Changes In the WildMarch 22, 2023Don’t you wish you could just look into the nucleus of a cell and watch what’s happening? With SiTomics, Peng Chen’s lab (Peking University) gets close—they can see what modifications are being placed on a particular histone, what proteins bind to it, and where that histone is on the DNA, all in living cells. To do […]
Going Green! – How Histone Recycling Promotes the Preservation of Pristine Epigenetic LandscapesMarch 6, 2023The climate crisis and our need to produce less waste have made recycling an everyday concept; however, whether histone proteins “go green” during DNA replication has remained somewhat in doubt. The epigenetic environment becomes disrupted during DNA replication and must be restored to maintain genome regulation and cell identity; now, two high-efficiency epigenetic studies provide […]
One-Stop Sequencing: Simultaneous Genetic and Epigenetic InformationMarch 2, 2023Some shoppers like to browse several stores, whereas others follow the Amazon approach and want to just visit one place to buy everything on their list. The lab of Shankar Balasubramanian’s (University of Cambridge) must be in that second group because they developed a sequencing method that is a true one-stop extravaganza. It rings up […]