eBook: RNA & TranscriptomicsOctober 13, 2023Analysis of the working of our RNA, from transcription and splicing to translation, began in a simpler time – when we talked about “RNA” and hadn’t yet recognized the whole range of RNA species, including miRNAs, ncRNAs, and more. These days, we are learning as much about the epigenetic modification of RNA and the role […]
Epigenetic Inheritance During DNA Replication: A State Lying Somewhere Between Symmetry and InstabilityOctober 2, 2023Emerging research has provided evidence for the critical importance of the inheritance of epigenetic states, whether that be DNA methylation, histone modifications, or even non-coding RNAs. Now, three recent studies focusing on the mechanism involved in passing down this information from parental to daughter cells while they replicate their DNA and divide in vitro provide […]
Let It Rain: Droplets Generate Single-Nuclei Multiomes of Either Histone or RNA ModificationsSeptember 25, 2023A downpour of single-cell and single-molecule multiomics methods are prompting us to exclaim, “Let it rain!” We recently told you about a couple of single-molecule epigenetic mapping methods involving chromatin. And now, two new papers show how using a droplet-based microfluidic platform can provide multiomic information about single-cell transcriptomes along with histone modifications or RNA […]
Keeping COVID-19 in the Family – SARS-CoV-2 Infection Reprograms Immune Responses Through Epigenetic MemorySeptember 24, 2023We try to keep exciting research findings in our epigenetic “family,” and a recent article now reports that our stem and immune cells are not so different when it comes to their epigenetic memory of SARS-CoV-2 infection! A new study now describes how SARS-CoV-2-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) severely impacts […]
Just Add HiDRO to Figure Out How Genomes Fold in Single CellsSeptember 14, 2023Water hydrates and is essential for life—for plants, humans, and even fish. So, it’s fitting that a new technique called HiDRO takes high-throughput FISH to the next level to identify factors that help genomes fold in 3D at high throughput in single cells. Cohesin helps DNA form loops, which can then form topologically associated domains (TADs). […]
