One More Reason to Eat Your Wheaties: Your Microbiome and Histone AcetylationFebruary 7, 2023We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research from Ben Garcia’s lab (WUSTL) gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly ward off diseases like […]
Chem-map: A New “GPS” to Pinpoint Where Small Molecules Bind ChromatinFebruary 7, 2023With all the GPS trackers and map apps out there, it’s almost impossible to get lost. But even though we know what a lot of small molecules are doing, we can lose track of exactly where those molecules are. That’s why Shankar Balasubramanian’s lab (University of Cambridge) developed Chem-map. Knowing this info could help researchers […]
You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!February 6, 2023Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? We know all too well about age-related epigenetic changes, and now a team led by […]
Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease RiskJanuary 30, 2023Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]
scChIX-seq Brings Double the Fun to Single-Cell Histone Modification ProfilingJanuary 23, 2023How do you double your fun? An extra scoop of ice cream, coffee and a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the scChIX-seq (single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while […]