Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence ProfileJanuary 31, 2022Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]
Like a RedChIP to a Bull! – New Technique Explores RNA-Protein-DNA InteractionsJanuary 30, 2022The publication of a new technique is like waving a red rag to a bull for many in the epigenetics arena. Now, “RedChIP” has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. Olé! Non-coding RNAs (ncRNAs) interact with proteins and DNA to […]
Architectural Woes Prompt Age-related Problems Thanks to Genes Lacking CpG IslandsJanuary 20, 2022As cracks to walls and beams can lead to an old house coming apart at the seams, the architectural alterations associated within an aging nucleus can prompt degenerative processes at the cell and tissue level. While any good architect can identify and help to sure up the problematic elements bringing down the house, the blueprints […]
scAge – A Single-cell DNA Methylation Clock Details Epigenetic Aging and RejuvenationJanuary 10, 2022With the new year comes a fresh start, but does the aging epigenome of each one of our cells share this sentiment? To help get your new year off to the right start, a new program known as “scAge” allows the determination of the age of single cells via DNA methylation and reveals insight into […]
A Suite of New Tools to Solve Single-cell Epigenetic EnigmasDecember 23, 2021Welcome explorers of the epigenome! Are you looking for new tools to help answer the toughest of epigenetic enigmas? Then check out this suite of single-cell methods papers from technologically-talented teams led by Aviv Regev (Broad Institute of MIT and Harvard) and collaborators. inCITE into How Transcription Factors Shape In Vivo Gene Expression A collaboration […]
