MYC Sequestration Mitigates Cancer Risk in iPSC TherapiesSeptember 30, 2014Mention “sequestration” in the US and scientists cringe at the memories of past budget freezes. But recently, a talented team of researchers has put the term in a more positive light; by sequestering MYC proteins in iPSCs, they’ve helped mitigate cancer risks in regenerative medicine. Since their first development in 2006, induced pluripotent stem cells […]
Inheritance of Histone Mod Caught at Cell divisionSeptember 29, 2014Transgenerational Epigenetic Inheritance is one of our favorite topics, it’s done a great job of showing old school Mendelian inheritance who’s boss by creating the molecular complexity of complex traits. With phenotypes and exposures aplenty, the one thing that has been missing is catching the inheritance of an acquired epigenetic mark in the act. And that’s just what a […]
Transcription Factor Networking Predicts Histone ModsSeptember 22, 2014Computational networking is all the rage, not only can it help you keep track of your friends and colleagues but it can also reveal a surprising amount of information behind the regulation of gene expression. Now a computationally cutting edge team from the University of Edinburgh have found out how to use transcription factor binding patterns […]
Environmental enrichment stimulates neural 5hmC dynamicsSeptember 17, 2014Judging from the luxurious lifestyles of the rich and famous, it would seem there’s no denying the wonders of an enriched environment. Even at an epigenetic scale, enhancing your environment properly and with a bit of personal restraint leads to improvements in the brain aplenty, including learning and memory. A team from Emory University characterized the […]
The IsomiR Comsos: Population and Gender DependanciesSeptember 17, 2014While microRNAs have been generally thought of as very homogenous little genomic modulators, some new studies are finding that there is actually an entire miRNA cosmos out there with slight variations that are relevant to gender and population differences in mammals. Over at Thomas Jefferson University, Isidore Rigoutsos and his colleagues have already seen some pretty […]