Intergenerational Epigenetic Inheritance with Dr. Elizabeth RadfordOctober 22, 2013Dr. Elizabeth Radford discusses some of the latest trends in intergenerational epigenetic inheritance. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Intergenerational Epigenetic Inheritance We’re collaborating with Mary-Elizabeth Patti who works at Harvard, and she has a mouse model where they undernourish […]
DNMT1-interacting RNAs (DiRs): DIY Methylation for the Locus that has EverythingOctober 18, 2013The holidays are just around the corner, but the gifts are arriving early as a talented crew of epigenetics enthusiasts published some great work in Nature last week that suggests some RNA transcripts have more self control than a Jedi. Look out Luke, these under appreciated RNAs fit DNMT1 like a glove, and block local DNA methylation. […]
We are the 98%: Intergenic Regions (Finally) Get Some BuzzOctober 11, 2013Many chose to focus on the ‘wealthy’ two percent of our genome that produces protein, but we’ve always found the other 98% to be much more interesting. Thankfully, we’re past the days of referring to non-coding, intergenic regions as ‘Junk DNA’, and new research is proving how scientifically rich they really are. Dr. Emily Hodges […]
A Crash Course in Folate, Nutrition, and DNA Methylation Regulation with Dr. Patrick StoverOctober 10, 2013Dr. Patrick Stover, PhD, the Director of the Division of Nutritional Sciences at Cornell University, provides a great overview of the key role of folate in one-carbon metabolism, and DNA methylation in nutrition. Folate, Nutrition, and DNA Methylation Regulation There’s a long history in the whole field of folate metabolism, one-carbon metabolism, that outcomes […]
R-Loops and GC-skew Predicts Epigenetic Effects of CpG IslandsOctober 9, 2013With the EpiGenie Fortune Telling Machine in the shop most of the time, it’s pretty difficult for us to predict much of anything. (Yeah, we didn’t see the whole ‘twerking’ phenomenon coming either!) But some enterprising researchers have developed a way to classify and predict the epigenetic and transcriptional activities of various promoter regions based […]
