miRNA Mimics Take Imperfect Aim at Gene PromotersMarch 29, 2011Sometimes a perfect match isn’t all it’s cracked up to be – just look at the Hollywood divorce rate. Whether you’re talking relationships or ncRNAs, a few mismatches between partners can still lead to a successful outcome. That seems to be the case for small RNAs that recognize gene promoter regions, as revealed by researchers […]
Making The ChIP Antibody GradesMarch 29, 2011Back in the 2000’s most researchers spent their post-ChIP analysis looking at a gel or a PCR curve. Now, they spend their analysis time combing through hard drives of sequencing data. A lot has changed in the world of location analysis, but the need for good antibodies remains the same; which is probably why we […]
LincRNA HOTTIP Gives Inside Info on Active Chromatin MarketsMarch 24, 2011In unsteady stock markets these days, who couldn’t use a hot tip to rev up their investments? Apparently, some HOXA genes also need a HOTTIP just as much as any Wall St. insider to help jump-start production. A recent Nature paper from talented teams at Stanford University and UCSF reveals that a long intergenic non-coding […]
Combo Your 5-hmC and 5-mC Detection with NEB’s EpiMark™ 5-hmC KitMarch 14, 2011If locus-specific DNA methylation is your game, then you already know that 5-hmC is something that you just can’t ignore. But setting up a round of experiments to figure out the 6th base’s role in your samples is no walk in the park, either. Happily, New England Biolabs has solved that quandary for you with […]
Epigenetics in Evolution with Dr Eva JablonkaMarch 13, 2011Dr. Eva Jablonka discusses the role of epigenetics in evolutionary biology. This short take was shot during a break at Keystone Symposia’s meeting on Environmental Epigenomics and Disease Susceptibility held in March 2011 in Asheville, North Carolina. Epigenetics in Evolution Well, what I’m doing really is theoretical work, and I’m mainly interested in the evolutionary […]
