Human Haploid ESCs – Half the DNA but Double the Potential?April 1, 2016Eyes, feet, hands, and chromosomes – two of each seems to be the done thing. Indeed, two sets of each chromosome (diploidy) is a general feature in mammals, except when we produce eggs and sperm (meiosis) which contain only one set of chromosomes (haploidy). However, various studies have described the production of embryonic stem cells […]
Location, Location, Location! Better Fluorescent Labeling For Protein And RNA LocalizationApril 1, 2016Location is important. But while we have great GPS tools to locate ourselves in the macro-world, microscopic things can be a bit harder to find. You might think it would be tough to lose something in as tiny a space as the inside of a cell, but that’s what I thought about my keys in […]
eBook: ChIP Reloaded | Recent Advances & Technical GuidanceMarch 25, 2016In this eBook, we’ve summarized several recent technical advances in ChIP that simplify the process and improve performance. Then we tossed in invaluable technical guidance from ChIP experts tackling every thing from working with challenging samples to data normalization. To top it all off, we’ve highlighted some new web applications that aim to streamline ChIP data analysis […]
CRISPR Trifecta Pays Off BigMarch 21, 2016If basic research drives innovation, the CRISPR-Cas system is one trophy-laden driver. Not long after its unexpected discovery as an obscure prokaryotic defense system against viruses, it has become the hottest thing since recombinant DNA. However, CRISPR’s intricate details still remain somewhat mysterious. Not to fear: basic research into CRISPR rolls on, with new, intriguing, […]
eBook: DNA Demethylation in DevelopmentMarch 19, 2016This ebook provides an introduction to the key cytosine base modifications: 5-methylcytosine, 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) that have been at the center of intense study in recent years. Inside, we’ve compiled numerous highlights that provide background on how these modifications function in DNA demethylation and also highlight the growing data that captures the role of demethylation […]
