Crush miRNA Function with miRZip anti-miRNA ConstructsApril 8, 2010The exact role miRNAs play in gene regulation may be an evolving story but that doesn’t mean you can’t pin down miRNA function in your model system. miRZip anti-miRNA vectors are a new breed of miRNA inhibitors that allow you to permanently knockdown miRNA function so you can analyze changes in phenotype more easily. Equipped with an H1 promoter, […]
Self Renewal: Yoga, Meditation and DNA MethyltransferasesApril 8, 2010Despite all the technology “progress” over the years that was supposed to save us heaps of time, we seem to be busier than ever. Real-time internet and PDAs make communication a 24-7 gig, so it’s no wonder that there’s a big movement in self-renewal. We would take some time here to give you small ways […]
Single Tube DNAm Analysis. Better Than Sliced Bread?April 6, 2010Tired of performing DNA extractions, bisulfite conversions, and PCR in three separate reactions? Is the sweet smell of phenol not helping you out with the opposite sex? Then, you’ll love DNA methylation analysis using methylation on beads (MOB)! Although it may sound like the stuff of infomercials, a team at Johns Hopkins University really found […]
Breaking Down miRNA MicroarraysApril 6, 2010As analysis of miRNAs becomes increasingly popular, the resulting flood of microarray products out there for miRNA profiling is enough to make your head spin. So how do you decide which ones to use? If you’ve been stressing over that question, you’ll be happy to know that some good folks at Cambridge Research Institute and […]
Transcription Enhancers Have an Oprah MomentMarch 30, 2010Not to get all “Oprah”, but sometimes, you need to let go of unstable elements in order to enhance your life. Researchers now report that this drama unfolds at the DNA level too. Here’s what they found: an unstable nucleosome sitting smack dab in the center of an enhancer can get kicked off to make […]