Two ES Cell Types Find Some Common GroundJanuary 6, 2010Coming from different backgrounds doesn’t make it impossible to find common ground. Just look at nuclear transfer-derived ES (ntES) and in vitro fertilized embryo-derived ES (IVFES) cells. Sure, they’re from different sides of the ES cell tracks, but as researchers from Michigan State University found out, once they’ve differentiated it hardly seems to matter. NtES […]
Zygotes Reboot On Paternal Methylation PatternsJanuary 6, 2010Kids often rebel against their parents as they grow up, and as it turns out, so do zygotes. Feeling “too cool” for their paternal sperm’s methylation patterns, zygotes assert their individuality by “rebooting” the inherited 5mCs and starting from scratch. But up until now, it was their little secret how they pulled it off. Researchers […]
RIP-Chip Tears Into miRNP Complex AnalysisJanuary 6, 2010Solving the mysteries of miRNA:mRNA interactions has been a tough case to crack. Correlation studies, and miRNA target prediction algorithms point us in the right direction, but their indirect nature is a little like going to trial with only circumstantial evidence. Researchers from University of Kentucky published a new paper demonstrating how RIP-Chip techniques can […]
Developing Technologies for Improved In Vivo Epigenetic Imaging/AnalysisDecember 15, 2009The NIH is opening up its wallet again for epigenetic technology development. $3.5M will be allocated in 2010 for developing in vivo epigenetic imaging and analysis technologies. According to the grant description, the NIH has recognized that “… the technologies available to determine the epigenetic state of tissues in vivo are extremely limited. The specific […]
Targeted Bisulfite Sequencing with Padlock ProbesDecember 8, 2009A rising star in the epigenetics field, Dr. Kun Zhang joined the UCSD faculty in 2007 after a post-doc with George Church at Harvard. Engaging in a little friendly competition with his former mentor, Zhang published a technique for targeted bisulfite sequencing using padlock probes (Nat. Biotechnol. 2009, 27, 353) at the same time the […]
