Twins Team Up to Help Unravel DNA Methylation in SchizophreniaMay 12, 2015While they can’t see through lead or stop bullets with their chest, twins do have a superpower of their own – when it comes to unraveling the complex genomic and epigenomic changes underlying diseases and disorders. In their latest adventure monozygotic twins are helping to understand the DNA methylation changes associated with schizophrenia. The epigenomics of […]
A TET-à-TET Between SIRT6 and 5hmC Controls Embryonic Stem Cell FateMay 12, 2015With many political parties fighting it out for influence in the UK general election last week, it is nice to see the spirit of cooperation alive and well in embryonic stem cells. In their latest study, Raul Mostoslavsky and colleagues show that two giants of epigenetic regulation, histone acetylation and DNA hydroxymethylation, team up to […]
6mA Makes the Grade as a Eukaryotic Epigenetic MarkMay 12, 2015There’s no denying that we love DNA methylation, so we are delighted to learn of another form of DNA methylation that has come on the scene as an epigenetic mark. N6-Methyladenosine (6mA or m6A) refers to the methylation of adenosine at its nitrogen-6 position, as opposed to 5mC and related oxidative marks (5hmC, 5fC, 5caC) that occur on […]
Upcycling the Epigenome in the Brain Help Neurons Stay in TouchMay 5, 2015Upcycling is the latest of many green crazes where people keep hold of old furniture and instead of throwing it away, they repurpose it to give new life. It seems that the brain might be doing the same for methylation. It’s been a long held belief that DNA methylation is fixed in differentiated cells, yet there is […]
None Shall Pass! Genome Editing Stops Heritable Diseases in Their TracksMay 4, 2015The scientific world is still reeling from the news of the first genome editing of human embryos to treat genetic disease, as we have reported previously here on Epigenie. Unfortunately, the paper suggested that this strategy may need huge improvement or may never be applicable. However, another recently published study, from the laboratory of Juan Carlos […]
