DNA Methylation Alterations Highlight Drivers of Aggressive Metastatic TumorsJuly 3, 2023The identification and early detection of events driving the metastasis of primary tumors may help identify therapeutic targets and patients that respond to specific therapeutics. Now, an epigenetic study focused on the spread of colorectal cancer to the liver reports DNA methylation as the spark driving metastatic events. Roadworthy researchers led by Euan J. Rodger, […]
Single-cell Epitranscriptomic Mapping of m6A from Small Samples with picoMeRIP-seqJuly 2, 2023Most successful epitranscriptomics studies rely on large amounts of input sample; however, huge findings may also reside in the smallest of specimens, such as zygotes or embryos. Now, a study provides exciting in vivo insight into these microcosms by describing the development of an epitranscriptomic mapping technique for single-cells and rare cell types. While traditional […]
X Chromosome vs. Autosome – m6A Helps to Level the RNA Stability Playing FieldJune 26, 2023While the single transcripts from the X chromosome may have a tough time competing with the one-two combination from their autosomal counterparts, heavy-hitting new findings now demonstrate that the m6A RNA modification lends a hand and levels the RNA stability playing field. The N6-methyladenosine RNA modification (m6A) recruits YTHDF proteins to reduce modified RNA stability […]
eBook: Chromatin & Gene ExpressionJune 14, 2023Gene expression is regulated by a range of factors, but ultimately begins with chromatin – it’s structure, configuration, activation, and “openness”. All of these factors can be dynamically regulated by epigenetics. In this eBook, we bring to your attention some of the most interesting articles in chromatin biology and gene expression, from practical methods to […]
Single-Molecule Methylation Profiles of Cell-Free Cancer DNA—Without Playing GamesJune 14, 2023Sometimes, you have to jump through a lot of hoops to get what you want. Hanlee Ji’s lab (Stanford) must be tired of playing those games because they’ve developed a direct single-molecule methylation nanopore sequencing approach for cell-free DNA (cfDNA) that doesn’t involve bisulfite conversion or even PCR. And yet it works on nanogram or […]