Is Cancer an Epigenomic Disease?October 7, 2013Discovering what ‘causes’ cancer has been a goal as elusive as hitting the Lottery by playing only the numbers in your birthdate. To complicate matters, most cases are unique events within themselves, adding a layer of heterogeneity that leads to even more hair-pulling frustration among researchers. However, cutting edge research has now revealed a possible […]
SNPs, Nutrition, and DNA Methylation with Dr. Steven ZeiselOctober 4, 2013Dr. Steven Zeisel discusses the intersection of genetics and epigenetics in nutrition. SNPs, Nutrition, and DNA Methylation Well, we think that there are a number of genetic variants, single nucleotide polymorphisms. I’ll call them SNPs. These SNPs are extremely common in one carbon metabolism, especially among Caucasians. And we are reporting that these SNPs […]
Get the Lead Out of Your EpigenomeOctober 1, 2013What’s mainly orange, sometimes a little black, and usually obese? Congratulations if you guessed Agouti (Avy) mice! (And you may want to consider spending less time in a vivarium) These chubby little creatures are well established as environmental epigenetics models because a number of environmental exposures are known to alter DNA methylation at the Avy […]
Charting Where Noncoding RNA Transcription Kicks OffSeptember 24, 2013While ‘Dark Matter’ is thought to constitute roughly 85% of the cosmos, our genomic dark matter (i.e. noncoding RNAs) makes up an even larger portion (~95%) of our genetic content. Leaving the vastness of outer space to astrophysicists, Dr. Bryan Venters and Dr. Franklin Pugh at Pennsylvania State University focused on creating a map of […]
Trinucleotide Repeat (TNR) Disease Cheat SheetSeptember 16, 2013Trinucleotide repeat (TNR) diseases are some of the latest disorders to be linked to epigenetic state. So Dr. Marguerite Evans-Galea and colleagues at the Murdoch Childrens Research Institute and The University of Melbourne, wrote up this review to act as a sort of cheat sheet for the mounting evidence of epigenetic mechanisms in TNR. This […]
