Modifying Our View of Histones with Dr. Jerry WorkmanDecember 3, 2013Dr. Jerry Workman discusses the questions surrounding the preservation of histone marks, and the balance between histone turnover and transgenerational inheritance. The Dynamic Histone Code I think one of the most exciting things for me that’s being approached in the field more recently is how are histone marks preserved? We talk about these things carrying […]
The Loose Ends in the Chromatin-Transcription Relationship with Dr. Steven HenikoffDecember 3, 2013Dr. Henikoff discusses some of the gaps in our understanding of transcription and chromatin that still need to be filled in. The Unknowns of RNA Polymerase-Nucleosome Interactions Well, you would think with so much work done on the relationship between transcription and chromatin, the fact that there’s so many meetings on it and all. We […]
Chemical Creation of Epigenetic Marks: One Step Closer to Synthetic LifeDecember 2, 2013What if Craig Ventor got a hold of the epigenome during his quest to create synthetic life? Is humanity be ready for an artificial life-form potentially as complex as its creators? Will Duck Dynasty and Honey Boo Boo be picked up for another season? These are all very important questions. And a few of our […]
Transgenerational Epigenetics is Bringing Sexy BackNovember 26, 2013For mice, domestication is a ten generation process, and while we’re left wondering at what stage Toronto Mayor Rob Ford is caught up in, we’ll try to steer clear of any low brow jokes. During the process of domestication many adaptations occur, but not all are beneficial. In fact, as a thought provoking group from […]
Genome Synthesis vs. DNA Methylation: A Battle for One-Carbon with Dr. Patrick StoverNovember 19, 2013Dr. Patrick Stover discusses the competition between genome synthesis and DNA methylation for the use of available folate and one-carbons. The Balancing Act of Folate Metabolism So one of the primary focus of our laboratory is trying to link how changes in metabolism affect specific disease outcomes. And we’re most interested in neural tube defects […]
