Genome Sequence Affects Heterochromatin SpreadingApril 17, 2009The establishment of heterochromatin is an important way for cells to repress transcription. Yet not much is known about the control of heterochromatin spreading into euchromatic domains. Therefore, researchers at Duke University used the Awesome Power of Yeast (Epi)Genetics to study how specific DNA sequences affect heterochromatin spreading. Their results are published in the April […]
Huh? miR-96 Tied to Hearing LossApril 17, 2009Over the years, mothers around the world have routinely warned their children of the imminent hearing loss resulting from too many Iron Maiden concerts, blasting Winger too loud on car stereos, or the permanently attached iPod earbuds that come standard with adolescents nowadays, but now we have scientific data to suggest our mothers and miR-96 […]
RIP Into RISC Proteins with System Biosciences’ miR-SNaREsApril 14, 2009Small Non-coding RNA Enrichment Can Be RISCy Things can get complicated when you are looking for low copy miRNAs, validating miRNA targets or trying to figure out all of the players in RISC complexes. SBI’s miR-SNaREs™, enable you to lasso those answers easily. The system uses Lentivectors to overexpress different flavors of epitope tagged microRNA processing […]
miRNA Promoter Analysis with Custom ChIP-Chip ArraysApril 11, 2009Last time we checked there weren’t any miRNA Promoter Arrays out there in the market and even if there were, they’d likely be out of date, so if you’re ready to roll up your lab sleeves and dive into the transcriptional regulation of miRNAs, you’ll want to check into custom array designs like Agilent’s eArray. These custom, ink […]
miRNA Promoter Elements Driving Cell-Specific ExpressionApril 10, 2009Whether you’re talking about real estate or miRNA expression, the phrase “location, location, location” expresses the undeniable importance of surroundings. Like protein-coding genes, miRNA genes can be turned on or off depending on the cellular context. However, mechanisms responsible for cell-specific miRNA expression are largely unknown because miRNA promoters are not as well characterized as […]
