EpiGenie 5hmC Technology GuideOctober 31, 2012A couple of years ago, researchers keen to analyze 5-hmC had a couple of options, but those early approaches couldn’t quite satisfy all of their increasing demands. Fast-forward a bit and it’s a very different story. Today there’s a plethora of options, each with its own strengths and weaknesses. As a result, one of the […]
This Stem Cell Reprogramming is Made Possible with Generous Support from Histone H3.3October 30, 2012Some people dress up their pets in clothes so that they will look more like their human owners. Turns out, a similar thing happens in the nuclear transfer process to make stem cells. Jerome Jullien and colleagues in 2012 Nobel laureate John B. Gurdon’s lab (along with a number of other great researchers in France […]
GC Content and CpG Islands Keep Chromatin Open for TranscriptionOctober 30, 2012The word “island” conjures up images of a tropical paradise with a sandy beach and a sunny sky—a nice place to hang out. In a similar way, CpG islands turn out to be nice places for Pol II to hang out without worrying about pesky nucleosomes getting in the way, according to researchers in France […]
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5-hmC Sequencing on a BudgetOctober 30, 2012Whether you’re the head of a lab, household, or leading a country, budgets are a reality. Like those old jeans you can’t seem to donate, they seem to get tighter every year. So when slick, new methods surface that tackle some tough challenges like single nucleotide resolution 5-hmC profiling, researchers’ excitement is quickly tempered by […]
