H4K16ac Marks an Intergenerational To-Do List for Developing Fly EmbryosJuly 7, 2020Do the laundry? Check. Buy fabric softener? Got it. Write that next manuscript? Working on it… We’ve all got a lot on our to-do lists these days, but it’s nothing compared to the checklist that developing drosophila embryos have to contend with. On top of coordinating histone methylation marks, they’ve got to prepare for a […]
Filling in the Blanks: DNA Methylation-Dependent Glycosylation of Chromatin Modifiers Represses TranscriptionJuly 7, 2020You might think our portrait of the marks that make up the epigenetic landscape is nearing completion, but a new feature is now filling in some of the blank space behind a key regulatory mechanism. It has been long known that DNA methylation represses transcription via the recruitment of methylation-dependent repressive factors. The components of […]
Early-Life BPA Exposure Accelerates Epigenetic Aging and Creates a Ticking Timebomb for Metabolic Disease that a Western Diet IgnitesJuly 3, 2020While we hope that any silly errors and childish pranks of our formative years don´t follow us into adulthood, it now seems that certain experiences during early development are indeed carried into adulthood without our knowledge, where an activating trigger can lead to trouble and strife! Specifically, exposure to any number of environmental stressors during […]
Disrupted LADs Drive Epigenetic Alterations in Human Early-onset AgingJune 22, 2020The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]
Epigenetic Hole-in-One: Methylation of a Single CpG Disrupts GATA-1 Binding and Regulates Gene ExpressionJune 11, 2020The GATA-1 transcription factor is like the Tiger Woods of the erythroid cell lineage, topping the leaderboard and driving the expression of important developmental genes. Other molecular competitors, like the NuRD complex, are already on the course, but a new study shows how methylation of a single CpG is able to score a hole-in-one to […]
