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Stem Cell News

Metabolic Modulation of Stem Cell Fate Through SIRT1

In our younger years our rampant metabolism meant we could eat what we wanted with little or no consequences. However, as we get older, our metabolism somehow gets “reprogrammed”, meaning all that … [Read More...]

SYNb

Kickstarting New Antibiotic Discovery with Microbial Dark Matter

Public health has a looming, if slow-simmering, crisis. Antibiotics, which revolutionized health care in the 20th century, are losing their punch. Evolution, it turns out, is pretty effective at … [Read More...]

dna-methylation

A Good Friend is Forever: DNMTs and Histone Complexes

It’s not always easy to find good friends, but recent work has found that the de novo DNA methyltransferases DNMT3A2 and DNMT3B1 are far from socially awkward. Baubec et al. from the Swiss team … [Read More...]

SYNb

The Latest and Greatest: A Genome-Editing Cautionary Tale

Genome-editing techniques, including CRISPR-Cas9 and TALENs, have leapt into the limelight through their ability to perform feats such as creating genetically engineered monkeys, ‘curing’ a human … [Read More...]

chromatin

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

The effect of epigenetic marks across generations has helped bring epigenetics to the public eye like never before. The health implications are enormous and so is the contribution to basic science, … [Read More...]

chromatin

Grab a New Epigenetics Scientist Job at ThermoFisher Scientific

If you're looking to start off 2015 with a new epigenetics job, our friends at ThermoFisher Scientific may the position for you, as a Scientist II - Epigenetics Biology at their Rockford, Illinois … [Read More...]

dna-methylation

Uncovering New Roles and Intimate Friends for TETs

5hmC was originally discovered way back in the 50's in bacteriophages and was first observed in mammals in the 70's, but research into this was set back when these studies failed to replicate. And … [Read More...]

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Stem Cell News

Metabolic Modulation of Stem Cell Fate Through SIRT1

In our younger years our rampant metabolism meant we could eat what we wanted with little or no consequences. However, as we get older, our metabolism somehow gets “reprogrammed”, meaning all that … [Read More...]

dna-methylation

A Good Friend is Forever: DNMTs and Histone Complexes

It’s not always easy to find good friends, but recent work has found that the de novo DNA methyltransferases DNMT3A2 and DNMT3B1 are far from socially awkward. Baubec et al. from the Swiss team … [Read More...]

dna-methylation

Abcam’s Bisulfite-Seq High Sensitivity Kit Streamlines the BS

The new Bisulfite-Seq High Sensitivity Kit from the creative crew at Abcam, is a 2-in-1 package that weaves bisulfite conversion, and Illumina® sequencing library prep into the same process. This … [Read More...]

chromatin

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

The effect of epigenetic marks across generations has helped bring epigenetics to the public eye like never before. The health implications are enormous and so is the contribution to basic science, … [Read More...]

chromatin

Grab a New Epigenetics Scientist Job at ThermoFisher Scientific

If you're looking to start off 2015 with a new epigenetics job, our friends at ThermoFisher Scientific may the position for you, as a Scientist II - Epigenetics Biology at their Rockford, Illinois … [Read More...]

dna-methylation

Uncovering New Roles and Intimate Friends for TETs

5hmC was originally discovered way back in the 50's in bacteriophages and was first observed in mammals in the 70's, but research into this was set back when these studies failed to replicate. And … [Read More...]

dna-methylation

Why Drugs in Dad Can Affect Your Epigenome

Some people aren’t always happy about what gets passed on from their parents. It’s great to have your Dad’s strong cheekbones but not so great to have his lactose intolerance. It turns out we may … [Read More...]

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SYNb

Kickstarting New Antibiotic Discovery with Microbial Dark Matter

Public health has a looming, if slow-simmering, crisis. Antibiotics, which revolutionized health care in the 20th century, are losing their punch. Evolution, it turns out, is pretty effective at … [Read More...]

SYNb

The Latest and Greatest: A Genome-Editing Cautionary Tale

Genome-editing techniques, including CRISPR-Cas9 and TALENs, have leapt into the limelight through their ability to perform feats such as creating genetically engineered monkeys, ‘curing’ a human … [Read More...]

technology

Genome Editing Timeline

Since its inception, the field of genetic engineering has introduced DNA to plenty of nips, tucks, and modifications all in the name of science. The latest evolution of these, genome editing, might be … [Read More...]

chromatin

Upcoming Webinar: Epigenetic Editing: Towards Reprogramming of Gene Expression

Epigenetic Editing (EGE) refers to the local rewriting of epigenetic marks which opens up innovative approaches for gene expression reprogramming. This webinar will present the current approaches to … [Read More...]

Stem Cell News

Alpha-ketoglutarate: Small Metabolite With Big Influence on Stem Cell Pluripotency

Many of us go through the morning ritual of picking up store-brewed coffee, although we could just as easily make it ourselves. Most mammalian cells feel the same about glutamine, which they require … [Read More...]

SYNb

Newly Evolved Ribozyme Is Proof-of-principle for the Origin of Life

Life is complicated. While that does apply to ordering your daily caffeine fix at Starbucks, what we’re talking about here is darwinian, entropy-defying, self-replicating life. Just to store, read, … [Read More...]

SYNb

Combating Compensation: Generation of a Human Haploid Cell Line

Cas9 has already been shown to be able to knock out up to kilobase-size fragments of DNA, making it a big hitter in the world of genome editing. But one of the biggest enemies for researchers using … [Read More...]

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Stem Cell News

Metabolic Modulation of Stem Cell Fate Through SIRT1

In our younger years our rampant metabolism meant we could eat what we wanted with little or no consequences. However, as we get older, our metabolism somehow gets “reprogrammed”, meaning all that … [Read More...]

Stem Cell News

Shedding Light on Stem Cell Therapy for Parkinson’s with Optogenetics

Red light means stop and green light means go? Apparently not for a few bright researchers who have recently used a novel technique to shed light on how cell replacement therapy for Parkinson’s … [Read More...]

Stem Cell News

Divide and Cancer? Stem Cell Divisions Impact Tissue’s Cancer Risk

One question has intrigued cancer researchers for decades: why are some tissues more susceptible to developing cancers than others? Genetic and lifestyle factors have been frequently cited as common … [Read More...]

Stem Cell News

Uncovering Neural Differentiation Step-by-Step

The Laetoli footprints made by humans 3.6 million years ago in Tanzania are perhaps the most famous footprints of all time. However, more recent footprints have been uncovered by the laboratories of … [Read More...]

Stem Cell News

Plotting the Path to Pluripotency Uncovers Key Role of DNA Methylation

If you've read our recent piece ‘Reprogramming Roadmap Reveals Fuzzy New Stem Cells' you’ll already know how “Project Grandiose” [1, 2], the brainchild of Andras Nagy, identified a new pluripotent … [Read More...]

Stem Cell News

A “Grandiose” Project Provides a Fuzzy New Future for iPSC Research

Induced pluripotent stem cell (iPSCs) research burst on to the scene in 2006 with a paper which has since spawned thousands of studies and has proved to be a quantum leap for regenerative medicine. … [Read More...]

Stem Cell News

Promoting Pluripotency: Vitamin C Modulates Stem Cell Specifc miRNAs

We all know “an apple a day, keeps the doctor away”, but it requires a lot of discipline to ensure that our diet contains enough vitamins. This holds especially true for the daily vitamin C uptake. … [Read More...]

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microRNAs Europe Meeting 2014

The microRNAs Europe Meeting is perhaps one of the best-kept secrets in the non coding RNA community. Similar to thos...

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Epigenomics of Common Diseases 2014

The 4th Wellcome Trust Epigenomics of Common Diseases conference in Cambridge brought together leading sci...

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Epigenetic plasticity: Implications in Neural (dys)function 2014

The latest EMBO workshop was held in ICVS in Braga on October 22-25th and focused on the state-of-the-art ...

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Chromatin and Epigenetics: From Omics to Single Cells

Abcam and co-organizers once again pulled off a delightful meeting – this time bridging two exciting approaches...

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World Congress of Psychiatric Genetics 2014

Copenhagen provided the scenic backdrop for this year’s World Congress of Psychiatric Genetics. About 883 participa...

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Nuclear RNA, Gene Regulation, and Chromatin Structure (2014 IMB Conference)

The 2014 IMB Meeting on Nuclear RNA, Gene Regulation, and Chromatin Structure took place from the 9t...

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Transcription and Chromatin

“An All-star lineup of presenters and a pleasant atmosphere made the 11th EMBL Transcription and Chromat...

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