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Stay on top of epigenetics, stem cell, and synthetic biology research with the latest headlines, special features, technology highlights, and conference action.

SYNb

Shifting Inheritance up a Gear with Gene Drives

Add one more to all the amazing things CRISPR can do: it is also the ultimate driving machine. Provided, of course, that you are a gene, and that your destination is any chromosome where you do not … [Read More...]

chromatin

Keeping SINEs Silenced with H3K9me3

Kids can be hard to handle, between dealing with drawing on the walls and public temper tantrums; therefore all parents need a successful tactic for keeping them under control. Short INterspersed … [Read More...]

Stem Cell News

Reducing Reoffending among Immature Cancer Cells: Rehabilitation by Transdifferentiation

Every gardener knows the key to successful weeding; extract the entire root because even a small section can regenerate the whole plant. When treating cancer, doctors are faced with the same problem. … [Read More...]

dna-methylation

5mC Enables MeCP2 to Turn Down the Volume of Long Genes

A number of teams have already spent time in trying to uncover the path that leads from MeCP2 disruption to Rett syndrome, a severe neurodevelopmental disorder in the autism spectrum. Adding detail to … [Read More...]

Stem Cell News

Researchers Don’t Miss a Beat with New Heart Chip

Chips, in most incarnations, are bad for the heart.  Whether you're frying them, baking them into cookies, or carrying one on your shoulder, chips are not cardiologist-approved. A new paper from Kevin … [Read More...]

Stem Cell News

iPSCs and CRISPR the Dynamic Duo of Regenerative Medicine

Laurel and Hardy, Peanut Butter and Jelly, Batman and Robin - can we now add iPSCs (induced pluripotent stem cells) and CRISPR to the list of famous duos? Linzhao Cheng (John Hopkins) certainly thinks … [Read More...]

dna-methylation

Get Hooked with 5hmC

While there's no doubting that one month of continuous cocaine exposure is going to have an effect on the brain, it seems that some of the molecular culprits behind the response and long-term effects … [Read More...]

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chromatin

Keeping SINEs Silenced with H3K9me3

Kids can be hard to handle, between dealing with drawing on the walls and public temper tantrums; therefore all parents need a successful tactic for keeping them under control. Short INterspersed … [Read More...]

dna-methylation

5mC Enables MeCP2 to Turn Down the Volume of Long Genes

A number of teams have already spent time in trying to uncover the path that leads from MeCP2 disruption to Rett syndrome, a severe neurodevelopmental disorder in the autism spectrum. Adding detail to … [Read More...]

dna-methylation

Get Hooked with 5hmC

While there's no doubting that one month of continuous cocaine exposure is going to have an effect on the brain, it seems that some of the molecular culprits behind the response and long-term effects … [Read More...]

non-coding-rna

miRNA Research Gets Specific Uncovering Numerous Novel Precursors

In this interview Dr Isidore Rigoutsos discusses his recent paper 'Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs' published in … [Read More...]

dna-methylation

Our Favorite Findings from the Epigenomic Roadmap

For those of you with a keen eye, you’ll have already noticed the mass of Epigenomic Roadmap Studies published in Nature in February. In order to help you navigate this mountain of results we’ve … [Read More...]

dna-methylation

Zymo Research 5-mC and Quest™ 5-hmC ELISAs Take DNA Methylation Screens Global

The concept of ‘Acting Locally’ has struck a chord with many folks these days on topics ranging from groceries to government, which makes it easy to forget the last part of that meme: which is to also … [Read More...]

non-coding-rna

Wrap Your Brain Around circRNA Function

Circular RNAs (circRNAs) are a diverse RNA species that regulate gene expression in some funky ways, like functioning as super absorbent miRNA sponges in mammalian cells. However, they also seem to be … [Read More...]

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SYNb

Shifting Inheritance up a Gear with Gene Drives

Add one more to all the amazing things CRISPR can do: it is also the ultimate driving machine. Provided, of course, that you are a gene, and that your destination is any chromosome where you do not … [Read More...]

SYNb

New Rising STARs of Transcriptional Activation

If you can pronounce CRISPR, you know RNA-mediated gene control has been a rising star in synthetic biology. In principle, RNA regulation allows gene circuits to have many more independent control … [Read More...]

SYNb

An Engineered Synergistic CRISPR/Cas9 Activator Complex for Genome-wide Transcriptional Control

  Presenter: Silvana Konermann, Graduate Student in Dr Feng Zhang's Lab at Massachusetts Institute of Technology Systematic interrogation of gene function requires the ability to perturb gene … [Read More...]

SYNb

Express Yourself with Light-activatable CRISPR-Cas9

Guess what? It seems that blue light has a lot more to offer than just helping with your winter time blues. It could also be just what your transcriptional activation system needs. Synthetic biology … [Read More...]

SYNb

Taming Transcription in Synthetic Gene Circuits

As a kid there was no greater feeling on a weekend shopping trip than being set loose on the Pick ‘N’ Mix, carefully choosing from the wealth of candy to create the perfect selection. Lucky for you … [Read More...]

SYNb

Plant Receptor Re-engineered to Hear “Drought!” From a New Signal

Don’t get me wrong, plants have a lot of things going for them. However, as Groot’s fellow Galaxy Guardians can attest, vocabulary isn’t one of them. It can be hard to communicate with plants, even … [Read More...]

SYNb

Transcriptional Activation: a New Trick for CRISPR-Cas9

We all know that the genome editing superhero CRISPR-Cas9 is a master of modifying the genome, but a recent paper from Zhang lab shows that it is more than just a one-trick pony. This latest research … [Read More...]

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Stem Cell News

Reducing Reoffending among Immature Cancer Cells: Rehabilitation by Transdifferentiation

Every gardener knows the key to successful weeding; extract the entire root because even a small section can regenerate the whole plant. When treating cancer, doctors are faced with the same problem. … [Read More...]

Stem Cell News

Researchers Don’t Miss a Beat with New Heart Chip

Chips, in most incarnations, are bad for the heart.  Whether you're frying them, baking them into cookies, or carrying one on your shoulder, chips are not cardiologist-approved. A new paper from Kevin … [Read More...]

Stem Cell News

iPSCs and CRISPR the Dynamic Duo of Regenerative Medicine

Laurel and Hardy, Peanut Butter and Jelly, Batman and Robin - can we now add iPSCs (induced pluripotent stem cells) and CRISPR to the list of famous duos? Linzhao Cheng (John Hopkins) certainly thinks … [Read More...]

non-coding-rna

How microRNAs Multi-task RNA Methylation to Enhance Reprogramming Efficiency

It’s no secret that microRNAs are pretty busy molecules. A single microRNA can regulate the expression of several, maybe even hundreds, of transcripts. If that wasn’t enough, researchers at … [Read More...]

Stem Cell News

Radiated Rodents Get Remyelinated Thanks to Stem Cell Treatment

Radiotherapy is an important and effective tool in the war against cancer, but its use for treating brain tumors brings with it unwanted side effects that can cause long term suffering to the patient. … [Read More...]

Stem Cell News

A Brief History of Cellular Transdifferentiation

For centuries, some of the world’s leading scholars worked endlessly with one objective, to turn ordinary metals into gold. Now, scientists of the 21st century are trying their hand at another type of … [Read More...]

Stem Cell News

Heritable Epigenetic Predisposition to Reprogramming

If epigenetics has taught us anything, it is that not all genetically identical beings are created equal. A team of stem-cell researchers from Tel Aviv University led by Iftach Nachman now apply this … [Read More...]

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Neuroepigenetics 2015

Researchers from the United States and around the world braved cancelations and layovers to finally find their way to...

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microRNAs Europe Meeting 2014

The microRNAs Europe Meeting is perhaps one of the best-kept secrets in the non coding RNA community. Similar to thos...

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Epigenomics of Common Diseases 2014

The 4th Wellcome Trust Epigenomics of Common Diseases conference in Cambridge brought together leading sci...

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Epigenetic plasticity: Implications in Neural (dys)function 2014

The latest EMBO workshop was held in ICVS in Braga on October 22-25th and focused on the state-of-the-art ...

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Chromatin and Epigenetics: From Omics to Single Cells

Abcam and co-organizers once again pulled off a delightful meeting – this time bridging two exciting approaches...

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World Congress of Psychiatric Genetics 2014

Copenhagen provided the scenic backdrop for this year’s World Congress of Psychiatric Genetics. About 883 participa...

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Nuclear RNA, Gene Regulation, and Chromatin Structure (2014 IMB Conference)

The 2014 IMB Meeting on Nuclear RNA, Gene Regulation, and Chromatin Structure took place from the 9t...

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