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Stay on top of epigenetics, stem cell, and synthetic biology research with the latest headlines, special features, technology highlights, and conference action.

SYNb

Spray Your Way Free of Cystic Fibrosis with a Gene Editing Nasal Spray

With allergy season around the corner, you might be turning to nasal sprays to relieve the symptoms. But now Marie Egan's lab at Yale University have developed a very different type of nasal spray … [Read More...]

technology

Catching RNA Polymerases in Action: New NETs for Higher Resolution

For a long time RNA polymerases did not get the credit they actually deserve. They have been viewed as muscle-cars at a drag race: Waiting for a start signal to race along the gene only stopping for … [Read More...]

technology

UPCOMING WEBINAR: Locus-specific biochemical analysis of genome functions using enChIP: an application of CRISPR/Cas to purification of specific genomic regions

  Register Now Date: 8 June 2015 Time: 4pm PST/ 7pm EST Presenter: Hodaka Fujii, M.D., Ph.D.  Research Institute for Microbial Diseases, Osaka University Abstract Elucidation of … [Read More...]

SYNb

Cas9 Gets an Illuminating Upgrade: Light-activatable Genome Editing

While dead Cas9 (dCas9) has been coupled to optogenetic systems to enable on the fly effector domain action, the not so dead Cas9 has just gotten a very different form of light induction that works … [Read More...]

non-coding-rna

Get in the Loop of Antisense Mediated Transcriptional Regulation

Long non-coding RNA research isn’t just a load of HOTAIR; since their initial discovery long non-coding RNAs have revealed their importance in regulating the genome. One such insight is the … [Read More...]

dna-methylation

Finding Epimutations in the Genome Haystack

Trying to identify DNA methylation mutations with current technologies usually requires a lot of cells, making it a lot like hunting for a needle in a haystack. Getting down to looking at single cells … [Read More...]

SYNb

CRISPR-Cas9 Gene Editing of Human Embryos: A Look at the Science

Unless you were on Mars or in the middle of a Netflix binge, you couldn't have missed the paper that has been hitting the headlines all over the world this week - the first example of the genetic … [Read More...]

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technology

Catching RNA Polymerases in Action: New NETs for Higher Resolution

For a long time RNA polymerases did not get the credit they actually deserve. They have been viewed as muscle-cars at a drag race: Waiting for a start signal to race along the gene only stopping for … [Read More...]

technology

UPCOMING WEBINAR: Locus-specific biochemical analysis of genome functions using enChIP: an application of CRISPR/Cas to purification of specific genomic regions

  Register Now Date: 8 June 2015 Time: 4pm PST/ 7pm EST Presenter: Hodaka Fujii, M.D., Ph.D.  Research Institute for Microbial Diseases, Osaka University Abstract Elucidation of … [Read More...]

non-coding-rna

Get in the Loop of Antisense Mediated Transcriptional Regulation

Long non-coding RNA research isn’t just a load of HOTAIR; since their initial discovery long non-coding RNAs have revealed their importance in regulating the genome. One such insight is the … [Read More...]

dna-methylation

Finding Epimutations in the Genome Haystack

Trying to identify DNA methylation mutations with current technologies usually requires a lot of cells, making it a lot like hunting for a needle in a haystack. Getting down to looking at single cells … [Read More...]

chromatin

Boosting Transcription with a Little Help from Histone Crotonylation

Every auto enthusiast knows that if you want to maximize the performance of your car, you’ve got to have the right parts in the right combination. While sometimes you may have to completely rebuild … [Read More...]

Stem Cell News

Pioneering Transcription Factors Wiggle Towards Pluripotency

Canoes, camels, cars and catamarans have carried human pioneers far and wide; taking us to undiscovered lands to encounter unseen beauty, encouraged by the hope of fame, glory, and a lust for … [Read More...]

Stem Cell News

Human Preimplantation Embryos Go Retroviral

Our genomes are littered with tales of our evolutionary past, including infections from retroviruses that have left their mark in the vast expanses of the human genome. While most of the endogenous … [Read More...]

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SYNb

Spray Your Way Free of Cystic Fibrosis with a Gene Editing Nasal Spray

With allergy season around the corner, you might be turning to nasal sprays to relieve the symptoms. But now Marie Egan's lab at Yale University have developed a very different type of nasal spray … [Read More...]

SYNb

Cas9 Gets an Illuminating Upgrade: Light-activatable Genome Editing

While dead Cas9 (dCas9) has been coupled to optogenetic systems to enable on the fly effector domain action, the not so dead Cas9 has just gotten a very different form of light induction that works … [Read More...]

SYNb

CRISPR-Cas9 Gene Editing of Human Embryos: A Look at the Science

Unless you were on Mars or in the middle of a Netflix binge, you couldn't have missed the paper that has been hitting the headlines all over the world this week - the first example of the genetic … [Read More...]

SYNb

CRISPR Goes Back to its Roots to Fight HIV

All the cool techniques people are developing with CRISPR-Cas9 are great and all, but sometimes a repurposed natural genetic system just has to go back to its roots. If CRISPR was originally a virus … [Read More...]

SYNb

Cancer Therapy Gets a Little Personal

Just like snowflakes we are all unique (at least genetically speaking), and unfortunately for modern medicine so are our cancers. This individuality in cancers, even of the same type or subtype, means … [Read More...]

SYNb

The Little Blue Pill Gets an Optogenetic Upgrade

While there's no denying that optogenetics is one stimulating piece of biotechnology, the double entendre of optogenetics being a 'turn on' has now become fact. The lab of Martin Fussenegger at ETH … [Read More...]

SYNb

CRISPR Gets Creative with Histone Acetylation

There's been a lot of firsts in the world of genome editing happening lately, from its application in human embryonic stem cells,  the identification of a smaller more versatile Cas9, to its upgrade … [Read More...]

View All Synthetic Biology
SYNb

CRISPR-Cas9 Gene Editing of Human Embryos: A Look at the Science

Unless you were on Mars or in the middle of a Netflix binge, you couldn't have missed the paper that has been hitting the headlines all over the world this week - the first example of the genetic … [Read More...]

Stem Cell News

Pioneering Transcription Factors Wiggle Towards Pluripotency

Canoes, camels, cars and catamarans have carried human pioneers far and wide; taking us to undiscovered lands to encounter unseen beauty, encouraged by the hope of fame, glory, and a lust for … [Read More...]

Stem Cell News

Human Preimplantation Embryos Go Retroviral

Our genomes are littered with tales of our evolutionary past, including infections from retroviruses that have left their mark in the vast expanses of the human genome. While most of the endogenous … [Read More...]

dna-methylation

The Differentiation Race: Not all Cells Move at the Same Speed

Christoph Bock discusses his recent paper 'Single-Cell DNA Methylome Sequencing and Bioinformatic Inference of Epigenomic Cell-State Dynamics' published in Cell Reports. Epigenetic Regulation of Cell … [Read More...]

Stem Cell News

Mass-tering the Stem Cell Reprogramming Process

Chaotic, uncoordinated, and seemingly without rhyme or reason…no, it’s not the daily stampede towards the barista for your first coffee of the day; rather it’s the words used to describe the early … [Read More...]

Stem Cell News

Young Mitochondria Maintain Stem Cell Self-renewal

For many commuters, good maintenance may make the difference between getting to work on time or waiting in the cold to be rescued from the roadside at 8:00 in the morning. Like any vehicle, a cell is … [Read More...]

dna-methylation

DNMT1 Loss is Lethal in Human But Not Mouse Embryonic Stem Cells

Mouse models have been great to science, they've given insight into humans in ways simply not possible in humans. However, while there are striking similarities in the epigenetics of mice and … [Read More...]

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Neuroepigenetics 2015

Researchers from the United States and around the world braved cancelations and layovers to finally find their way to...

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microRNAs Europe Meeting 2014

The microRNAs Europe Meeting is perhaps one of the best-kept secrets in the non coding RNA community. Similar to thos...

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Epigenomics of Common Diseases 2014

The 4th Wellcome Trust Epigenomics of Common Diseases conference in Cambridge brought together leading sci...

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Epigenetic plasticity: Implications in Neural (dys)function 2014

The latest EMBO workshop was held in ICVS in Braga on October 22-25th and focused on the state-of-the-art ...

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Chromatin and Epigenetics: From Omics to Single Cells

Abcam and co-organizers once again pulled off a delightful meeting – this time bridging two exciting approaches...

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World Congress of Psychiatric Genetics 2014

Copenhagen provided the scenic backdrop for this year’s World Congress of Psychiatric Genetics. About 883 participa...

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Nuclear RNA, Gene Regulation, and Chromatin Structure (2014 IMB Conference)

The 2014 IMB Meeting on Nuclear RNA, Gene Regulation, and Chromatin Structure took place from the 9t...

[Read More]
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